Publications

1. Zhou et al., Generation of Induced Pluripotent Stem Cells Using Recombinant Proteins, Cell Stem Cell (2009), doi:10.1016/j.stem.2009.04.005
2. LaFevre BM, Wu S. & Lin X. Recombinant, refolded tetrameric p53 and gonadotropin-releasing hormone-p53 slow proliferation and induce apoptosis in p53-deficient cancer cells. Molecular Cancer Therapeutics 7, 1420-1429, June 1, 2008. doi: 10.1158/1535-7163
3. Medynski D., Tuan M., Liu, W., Wu, S. & Lin, X. Refolding, purification, and activation of miniplasminogen and microplasminogen isolated from E. coli inclusion bodies. Protein Expression and Purification Volume 52, Issue 2, April 2007, Pages 395-402
4. Hou W., Medynski D., Wu, S., Lin, X. & Li, LY. VEGI-192, a New Isoform of TNFSF15, Specifically Eliminates Tumor Vascular Endothelial Cells and Suppresses Tumor Growth. Clinical Cancer Research Vol. 11, 5595-5602, August 1, 2005
5. Chew LJ, Pan H, Yu J, Tian S, Huang WQ, Zhang JY, Pang S, Li LY. A novel secreted splice variant of vascular endothelial cell growth inhibitor. FASEB J. 2002 Mar 26.
6. Yong-Tae Kim, Deborah Downs, Shili Wu, Azar Dashti, Yujun Pan, Peng Zhai, Xinjuan Wang, Xuejun C. Zhang and Xinli Lin. (2002) "Enzymic Properties of Recombinant BACE2". Eur. J. Biochem. 269:1-11.
7. Yu J, Tian S, Metheny-Barlow L, Chew LJ, Hayes AJ, Pan H, Yu GL, Li LY. Modulation of endothelial cell growth arrest and apoptosis by vascular endothelial growth inhibitor. Circ Res. 2001 Dec 7;89(12):1161-7.
8. Wang, X., Terzyan, S., Tang, J., Loy, J. A., Lin, X. & Zhang, X. C. (2000) "Human plasminogen catalytic domain undergoes an unusual conformational change upon activation". J Mol Biol 295: 903-14.
9. Lin, X., Koelsch, G., Wu, S., Downs, D., Dashti, A. & Tang, J. (2000) "Human aspartic protease memapsin 2 cleaves the b-secretase site of b-amyloid precursor protein". Proc. Natl. Acad. Sci. USA 97: 1456-1460.
10. Ghosh, A. K., Shin, D., Downs, D., Koelsch, G., Lin, X., Ermolieff, J. & Tang, J. (2000) "Design of potent inhibitors for human brain memapsin 2 (beta-secretase)". J. Am. Chem. Soc. 122: 3522-3523.
11. Hong, L., Koelsch, G., Lin, L., Wu, S., Terzyan, S., Ghosh, A., Zhang, X. & Tang, J. (2000) "Structure of Memapsin 2 (beta-secretase) complexed with inhibitor: a template to design drugs for Alzheimer's Disease". Science 290: 150-153.
12. Koelsch, G., Tang, J., Loy, J. A., Monod, M., Jackson, K., Foundling, S. I. & Lin, X. (2000) "Enzymic characteristics of secreted aspartic proteases of Candida albicans". Biochim Biophys Acta 1480: 117-131.
13. Zhai Y, Yu J, Iruela-Arispe L, Huang WQ, Wang Z, Hayes AJ, Lu J, Jiang G, Rojas L, Lippman ME, Ni J, Yu GL, Li LY. Inhibition of angiogenesis and breast cancer xenograft tumor growth by VEGI, a novel cytokine of the TNF superfamily. Int J Cancer. 1999 Jul 2;82(1):131-6.
14. Zhai Y, Ni J, Jiang GW, Lu J, Xing L, Lincoln C, Carter KC, Janat F, Kozak D, Xu S, Rojas L, Aggarwal BB, Ruben S, Li LY, Gentz R, Yu GL. VEGI, a novel cytokine of the tumor necrosis factor family, is an angiogenesis inhibitor that suppresses the growth of colon carcinomas in vivo. FASEB J. 1999 Jan;13(1):181-9.
15. Faro, C., Ramal-Santos, M., Vieira, M., Mendes, A., Simoes, I., Andrade, R., Verissimo, P., Lin, X., Tang, J. & Peres, E. (1999) "Cloning and characterization of cDNA encoding cardosin A, and RGD containing plant aspartic proteinase". J. Biol. Chem. 274: 28724-28729.
16. Wang, X., Lin, X., Loy, J. A., Tang, J., Zhang, X. C. (1998) "Crystal structure of the catalytic domain of human plasmin complexed with streptokinase". Science 281: 1662-1665.

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